Assay Detail
Binding
CHEMBL4384747
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells by Qpatch assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.16 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456312 | — | — | 1 | 5.28 |
| CHEMBL4547537 | — | — | 1 | 5.10 |
| CHEMBL4461475 | — | — | 1 | 5.10 |
| CHEMBL4439190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456312 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4547537 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4461475 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4439190 | — | IC50 | > | 10000.0 | nM | - |