Assay Detail
Functional
CHEMBL4384786
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 4.89 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.50 |
| CHEMBL4447355 | — | — | 1 | 5.03 |
| CHEMBL4519344 | — | — | 1 | 5.02 |
| CHEMBL4563352 | — | — | 1 | 4.97 |
| CHEMBL4466044 | — | — | 1 | 4.93 |
| CHEMBL4515181 | — | — | 1 | 4.91 |
| CHEMBL4483426 | — | — | 1 | 4.86 |
| CHEMBL4567612 | — | — | 1 | 4.76 |
| CHEMBL4516322 | — | — | 1 | 4.76 |
| CHEMBL4516962 | — | — | 1 | 4.72 |
| CHEMBL458934 | CAMBOGIN | — | 1 | 4.72 |
| CHEMBL4522763 | — | — | 1 | 4.71 |
| CHEMBL4574256 | — | — | 1 | 4.70 |
| CHEMBL4456220 | — | — | 1 | - |
| CHEMBL4440115 | — | — | 1 | - |
| CHEMBL4556095 | — | — | 1 | - |
| CHEMBL4453811 | — | — | 1 | - |
| CHEMBL4558234 | — | — | 1 | - |
| CHEMBL4526517 | — | — | 1 | - |
| CHEMBL4530752 | — | — | 1 | - |
| CHEMBL4437501 | — | — | 1 | - |
| CHEMBL4468654 | — | — | 1 | - |
| CHEMBL4572111 | — | — | 1 | - |
| CHEMBL4441370 | — | — | 1 | - |
| CHEMBL4468162 | — | — | 1 | - |
| CHEMBL4450685 | — | — | 1 | - |
| CHEMBL4446994 | — | — | 1 | - |
| CHEMBL4449077 | — | — | 1 | - |
| CHEMBL4472259 | — | — | 1 | - |
| CHEMBL4469826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4447355 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL4519344 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL4563352 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4466044 | — | IC50 | = | 11720.0 | nM | 4.93 |
| CHEMBL4515181 | — | IC50 | = | 12320.0 | nM | 4.91 |
| CHEMBL4483426 | — | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL4567612 | — | IC50 | = | 17210.0 | nM | 4.76 |
| CHEMBL4516322 | — | IC50 | = | 17240.0 | nM | 4.76 |
| CHEMBL4516962 | — | IC50 | = | 19220.0 | nM | 4.72 |
| CHEMBL458934 | CAMBOGIN | IC50 | = | 19210.0 | nM | 4.72 |
| CHEMBL4522763 | — | IC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL4574256 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4556095 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4440115 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4456220 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446656 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4473330 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4466894 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4448136 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4447028 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446988 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4530933 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4588099 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4442136 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4442080 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453811 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4558234 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4526517 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4530752 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4437501 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4468654 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4572111 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4441370 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4468162 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4450685 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446994 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4449077 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4472259 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4469826 | — | IC50 | > | 20000.0 | nM | - |