Assay Detail
Functional
CHEMBL4384820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.82 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 7.66 |
| CHEMBL4452846 | — | — | 1 | 6.92 |
| CHEMBL4559579 | — | — | 1 | 6.70 |
| CHEMBL4562093 | — | — | 1 | 6.52 |
| CHEMBL4530765 | — | — | 1 | 6.30 |
| CHEMBL4554182 | — | — | 1 | 6.29 |
| CHEMBL4583364 | — | — | 1 | 6.27 |
| CHEMBL4541802 | — | — | 1 | 6.24 |
| CHEMBL4552994 | — | — | 1 | 6.22 |
| CHEMBL4545878 | — | — | 1 | 6.22 |
| CHEMBL4465190 | — | — | 1 | 6.05 |
| CHEMBL4453579 | — | — | 1 | 6.00 |
| CHEMBL4548509 | — | — | 1 | 5.96 |
| CHEMBL4564346 | — | — | 1 | 5.75 |
| CHEMBL4518638 | — | — | 1 | 5.64 |
| CHEMBL4591781 | — | — | 1 | 5.62 |
| CHEMBL4437831 | — | — | 1 | 5.62 |
| CHEMBL4588210 | — | — | 1 | 5.57 |
| CHEMBL4457390 | — | — | 1 | 5.46 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.42 |
| CHEMBL4456186 | — | — | 1 | 5.40 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.38 |
| CHEMBL4470783 | — | — | 1 | 5.36 |
| CHEMBL4458860 | — | — | 1 | 5.34 |
| CHEMBL4560318 | — | — | 1 | 5.30 |
| CHEMBL4519374 | — | — | 1 | 5.28 |
| CHEMBL4442200 | — | — | 1 | 5.16 |
| CHEMBL4589675 | — | — | 1 | 5.04 |
| CHEMBL4473120 | — | — | 1 | 5.00 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4452846 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4559579 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4562093 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4530765 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4554182 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4583364 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4541802 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4552994 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4545878 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4465190 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4453579 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4548509 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4564346 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4518638 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4591781 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4437831 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4588210 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4457390 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL535 | SUNITINIB | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4456186 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4470783 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4458860 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4560318 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4519374 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4442200 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4589675 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4473120 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 17000.0 | nM | 4.77 |