Assay Detail
Functional
CHEMBL4384822
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Antiproliferative activity against human HeLa cells by MTT assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.07 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 1 | 8.59 |
| CHEMBL4559579 | — | — | 1 | 6.92 |
| CHEMBL4562093 | — | — | 1 | 6.77 |
| CHEMBL4545878 | — | — | 1 | 6.58 |
| CHEMBL4530765 | — | — | 1 | 6.54 |
| CHEMBL4583364 | — | — | 1 | 6.52 |
| CHEMBL4541802 | — | — | 1 | 6.52 |
| CHEMBL4452846 | — | — | 1 | 6.52 |
| CHEMBL4552994 | — | — | 1 | 6.47 |
| CHEMBL4554182 | — | — | 1 | 6.42 |
| CHEMBL4453579 | — | — | 1 | 6.35 |
| CHEMBL4465190 | — | — | 1 | 6.26 |
| CHEMBL4548509 | — | — | 1 | 6.17 |
| CHEMBL4560318 | — | — | 1 | 6.06 |
| CHEMBL4588210 | — | — | 1 | 5.97 |
| CHEMBL4564346 | — | — | 1 | 5.85 |
| CHEMBL4591781 | — | — | 1 | 5.82 |
| CHEMBL4589675 | — | — | 1 | 5.82 |
| CHEMBL4437831 | — | — | 1 | 5.80 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.68 |
| CHEMBL4442200 | — | — | 1 | 5.67 |
| CHEMBL4518638 | — | — | 1 | 5.58 |
| CHEMBL4456186 | — | — | 1 | 5.54 |
| CHEMBL4457390 | — | — | 1 | 5.54 |
| CHEMBL4458860 | — | — | 1 | 5.50 |
| CHEMBL4470783 | — | — | 1 | 5.47 |
| CHEMBL4519374 | — | — | 1 | 5.35 |
| CHEMBL4473120 | — | — | 1 | 5.35 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.21 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4559579 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4562093 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4545878 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4530765 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4583364 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4541802 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4452846 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4552994 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4554182 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4453579 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4465190 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4548509 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4560318 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4588210 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4564346 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4591781 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4589675 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4437831 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4442200 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4518638 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4456186 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4457390 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4458860 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4470783 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4519374 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4473120 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7800.0 | nM | 5.11 |