Assay Detail
Functional
CHEMBL4384887
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Antiangiogenic activity against HMEC1 cells after 20 hrs by tube formation assay
28
Total Activities
13
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3'-aminocombretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.51 | 7.92 |
| MAC | 13 | - | - |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330407 | — | — | 2 | 7.92 |
| CHEMBL4452846 | — | — | 3 | 6.52 |
| CHEMBL4583364 | — | — | 2 | 5.96 |
| CHEMBL4453579 | — | — | 2 | 5.70 |
| CHEMBL4554182 | — | — | 3 | 5.52 |
| CHEMBL4548509 | — | — | 2 | 5.40 |
| CHEMBL4437831 | — | — | 2 | 5.22 |
| CHEMBL535 | SUNITINIB | 4.0 | 2 | 5.16 |
| CHEMBL4457390 | — | — | 2 | 5.13 |
| CHEMBL4456186 | — | — | 2 | 4.89 |
| CHEMBL1336 | SORAFENIB | 4.0 | 2 | 4.47 |
| CHEMBL4470783 | — | — | 2 | 4.22 |
| CHEMBL4518638 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330407 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4452846 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4583364 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4453579 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4554182 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4548509 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4437831 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4457390 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4456186 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4470783 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL330407 | — | MAC | = | 0.003 | uM | - |
| CHEMBL535 | SUNITINIB | MAC | = | 3.0 | uM | - |
| CHEMBL1336 | SORAFENIB | MAC | = | 10.0 | uM | - |
| CHEMBL4554182 | — | MAC | = | 0.1 | uM | - |
| CHEMBL4554182 | — | Activity | - | — | - | |
| CHEMBL4518638 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL4518638 | — | MAC | = | 1.0 | uM | - |
| CHEMBL4456186 | — | MAC | = | 3.0 | uM | - |
| CHEMBL4452846 | — | Activity | - | — | - | |
| CHEMBL4453579 | — | MAC | = | 0.3 | uM | - |
| CHEMBL4457390 | — | MAC | = | 3.0 | uM | - |
| CHEMBL4548509 | — | MAC | = | 1.0 | uM | - |
| CHEMBL4470783 | — | MAC | = | 3.0 | uM | - |
| CHEMBL4452846 | — | MAC | = | 0.1 | uM | - |
| CHEMBL4437831 | — | MAC | = | 3.0 | uM | - |
| CHEMBL4583364 | — | MAC | = | 0.3 | uM | - |