Assay Detail
Binding
CHEMBL4385037
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Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based fluorescence assay
16
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.89 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450595 | — | — | 2 | 8.96 |
| CHEMBL4439889 | — | — | 2 | 8.49 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.29 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.26 |
| CHEMBL3707394 | SEMBRAGILINE | 2.0 | 1 | 8.23 |
| CHEMBL4450144 | — | — | 2 | 7.96 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.89 |
| CHEMBL4467747 | — | — | 2 | 7.54 |
| CHEMBL4532884 | — | — | 1 | 7.34 |
| CHEMBL4456254 | — | — | 1 | 7.14 |
| CHEMBL4451278 | — | — | 1 | 6.92 |
| CHEMBL4441316 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450595 | — | IC50 | = | 1.11 | nM | 8.96 |
| CHEMBL4450595 | — | IC50 | = | 1.122 | nM | 8.95 |
| CHEMBL4439889 | — | IC50 | = | 3.236 | nM | 8.49 |
| CHEMBL4439889 | — | IC50 | = | 3.27 | nM | 8.48 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL972 | SELEGILINE | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3707394 | SEMBRAGILINE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4450144 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL4450144 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL887 | RASAGILINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4467747 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL4467747 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL4532884 | — | IC50 | = | 46.1 | nM | 7.34 |
| CHEMBL4456254 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4451278 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4441316 | — | IC50 | = | 277.0 | nM | 6.56 |