Assay Detail
Binding
CHEMBL4385039
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Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by Cheng-Prusoff equation analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.60 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450595 | — | — | 1 | 9.30 |
| CHEMBL4439889 | — | — | 1 | 8.84 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.64 |
| CHEMBL4450144 | — | — | 1 | 8.32 |
| CHEMBL3319242 | — | — | 1 | 8.26 |
| CHEMBL4467747 | — | — | 1 | 7.89 |
| CHEMBL4532884 | — | — | 1 | 7.69 |
| CHEMBL4456254 | — | — | 1 | 7.50 |
| CHEMBL4451278 | — | — | 1 | 7.27 |
| CHEMBL4441316 | — | — | 1 | 6.91 |
| CHEMBL4467709 | — | — | 1 | 6.41 |
| CHEMBL3319241 | — | — | 1 | 5.94 |
| CHEMBL3319240 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450595 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4439889 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL396778 | SAFINAMIDE | Ki | = | 2.29 | nM | 8.64 |
| CHEMBL4450144 | — | Ki | = | 4.82 | nM | 8.32 |
| CHEMBL3319242 | — | Ki | = | 5.48 | nM | 8.26 |
| CHEMBL4467747 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL4532884 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL4456254 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL4451278 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL4441316 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL4467709 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3319241 | — | Ki | = | 1145.0 | nM | 5.94 |
| CHEMBL3319240 | — | Ki | = | 1459.0 | nM | 5.84 |