Assay Detail
ADMET
CHEMBL4385489
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Cytotoxicity against human THLE cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.65 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559065 | — | — | 1 | 5.10 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 4.96 |
| CHEMBL4442732 | — | — | 1 | 4.82 |
| CHEMBL4572913 | — | — | 1 | 4.82 |
| CHEMBL4440096 | — | — | 1 | 4.37 |
| CHEMBL4556666 | — | — | 1 | 4.31 |
| CHEMBL4591391 | — | — | 1 | 4.17 |
| CHEMBL4560385 | — | — | 1 | - |
| CHEMBL4518667 | — | — | 1 | - |
| CHEMBL4548556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559065 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4442732 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4572913 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4440096 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4556666 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4591391 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4560385 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL4518667 | — | IC50 | - | — | - | |
| CHEMBL4548556 | — | IC50 | = | 149000.0 | nM | - |