Assay Detail
Binding
CHEMBL4385720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged recombinant human full length PI3K p110alpha/p85alpha expressed in baculovirus expression system using lipid substrate incubated for 60 mins by kinase-Glo reagent based luminescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.70 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453364 | — | — | 1 | 6.00 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 5.67 |
| CHEMBL4468379 | — | — | 1 | 5.44 |
| CHEMBL4520088 | — | — | 1 | - |
| CHEMBL4471020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453364 | — | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 2164.0 | nM | 5.67 |
| CHEMBL4468379 | — | IC50 | = | 3637.0 | nM | 5.44 |
| CHEMBL4520088 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4471020 | — | IC50 | > | 5000.0 | nM | - |