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Assay Detail

CHEMBL4385970

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Functional
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant measured after 72 hrs by MTT assay
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Yuan X, Chen Y, Zhang W, He J, Lei L, Tang M, Liu J, Li M, Dou C, Yang T, Yang L, Yang S, Wei Y, Peng A, Niu T, Xiang M, Ye H, Chen L.
J Med Chem (2019) 62 : 4158 -4173
PubMed 30939008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 9.10 10.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4440175 — — 1 10.49
CHEMBL4517711 — — 1 10.37
CHEMBL4572804 — — 1 10.16
CHEMBL4439404 — — 1 10.05
CHEMBL4435360 — — 1 10.00
CHEMBL4526888 — — 1 9.97
CHEMBL4551114 — — 1 9.88
CHEMBL4575519 — — 1 9.83
CHEMBL4475375 — — 1 9.82
CHEMBL4557634 — — 1 9.51
CHEMBL4515336 — — 1 9.48
CHEMBL4435457 — — 1 9.43
CHEMBL4441875 — — 1 9.39
CHEMBL4461531 — — 1 9.38
CHEMBL4483045 — — 1 9.36
CHEMBL576982 QUIZARTINIB 4.0 1 9.35
CHEMBL4572972 — — 1 9.32
CHEMBL4459941 — — 1 9.22
CHEMBL4541344 — — 1 9.06
CHEMBL4439044 — — 1 8.87
CHEMBL4553847 — — 1 8.83
CHEMBL4586009 — — 1 8.76
CHEMBL4551816 — — 1 8.76
CHEMBL4569015 — — 1 8.76
CHEMBL4591906 — — 1 8.76
CHEMBL4441629 — — 1 8.76
CHEMBL4442278 — — 1 8.75
CHEMBL4532475 — — 1 8.70
CHEMBL4529106 — — 1 8.67
CHEMBL4472511 — — 1 8.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4440175 — IC50 = 0.032 nM 10.49
CHEMBL4517711 — IC50 = 0.043 nM 10.37
CHEMBL4572804 — IC50 = 0.069 nM 10.16
CHEMBL4439404 — IC50 = 0.089 nM 10.05
CHEMBL4435360 — IC50 = 0.1 nM 10.00
CHEMBL4526888 — IC50 = 0.107 nM 9.97
CHEMBL4551114 — IC50 = 0.131 nM 9.88
CHEMBL4575519 — IC50 = 0.149 nM 9.83
CHEMBL4475375 — IC50 = 0.152 nM 9.82
CHEMBL4557634 — IC50 = 0.311 nM 9.51
CHEMBL4515336 — IC50 = 0.329 nM 9.48
CHEMBL4435457 — IC50 = 0.376 nM 9.43
CHEMBL4441875 — IC50 = 0.403 nM 9.39
CHEMBL4461531 — IC50 = 0.422 nM 9.38
CHEMBL4483045 — IC50 = 0.434 nM 9.36
CHEMBL576982 QUIZARTINIB IC50 = 0.452 nM 9.35
CHEMBL4572972 — IC50 = 0.476 nM 9.32
CHEMBL4459941 — IC50 = 0.602 nM 9.22
CHEMBL4541344 — IC50 = 0.876 nM 9.06
CHEMBL4439044 — IC50 = 1.343 nM 8.87
CHEMBL4553847 — IC50 = 1.468 nM 8.83
CHEMBL4551816 — IC50 = 1.756 nM 8.76
CHEMBL4569015 — IC50 = 1.746 nM 8.76
CHEMBL4591906 — IC50 = 1.753 nM 8.76
CHEMBL4441629 — IC50 = 1.751 nM 8.76
CHEMBL4586009 — IC50 = 1.734 nM 8.76
CHEMBL4442278 — IC50 = 1.788 nM 8.75
CHEMBL4532475 — IC50 = 1.977 nM 8.70
CHEMBL4529106 — IC50 = 2.16 nM 8.67
CHEMBL4449006 — IC50 = 2.179 nM 8.66
CHEMBL4472511 — IC50 = 2.208 nM 8.66
CHEMBL4454804 — IC50 = 2.336 nM 8.63
CHEMBL4449318 — IC50 = 2.536 nM 8.60
CHEMBL4457542 — IC50 = 2.94 nM 8.53
CHEMBL4558160 — IC50 = 3.223 nM 8.49
CHEMBL4539069 — IC50 = 3.923 nM 8.41
CHEMBL4533761 — IC50 = 5.133 nM 8.29
CHEMBL4553033 — IC50 = 5.842 nM 8.23
CHEMBL4468986 — IC50 = 10.32 nM 7.99
CHEMBL4438587 — IC50 = 14.17 nM 7.85