Assay Detail

CHEMBL4386378

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Functional

Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains.

Naaz F, Haider MR, Shafi S, Yar MS.
Eur J Med Chem (2019) 171 : 310 -331
PubMed 30953881 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.37	7.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3349894	ANSAMITOCIN P3	—	1	7.82
CHEMBL4434869	—	—	1	6.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3349894	ANSAMITOCIN P3	IC50	=	15.06	nM	7.82
CHEMBL4434869	—	IC50	=	120.0	nM	6.92