Assay Detail

CHEMBL4386383

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Functional

Antiproliferative activity against human U937 cells assessed as reduction in cell growth

ChEMBL ↗

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Target

U-937 (CHEMBL612794) ↗

Open DB target context

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Primary target U-937

CHEMBL612794

Anchored from Assay target.

Protein identity U-937

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-937
Confidence	1 — Organism
Curated By	Autocuration

Target

U-937 (CHEMBL612794) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains.

Naaz F, Haider MR, Shafi S, Yar MS.
Eur J Med Chem (2019) 171 : 310 -331
PubMed 30953881 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.54	8.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL582439	ZAMPANOLIDE	—	1	8.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL582439	ZAMPANOLIDE	IC50	=	2.9	nM	8.54