Assay Detail

CHEMBL4386392

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Functional

Cytotoxicity against human CA46 cells assessed as inhibition of tubulin polymerization after 36 hrs

ChEMBL ↗

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Target

CA46 (CHEMBL612566) ↗

Open DB target context

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CA46 (CHEMBL612566) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target CA46

CHEMBL612566

Anchored from Assay target.

Protein identity CA46

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CA46
Confidence	1 — Organism
Curated By	Autocuration

Target

CA46 (CHEMBL612566) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains.

Naaz F, Haider MR, Shafi S, Yar MS.
Eur J Med Chem (2019) 171 : 310 -331
PubMed 30953881 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.70	5.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL77552	CENTAUREIDIN	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL77552	CENTAUREIDIN	IC50	=	2000.0	nM	5.70