Assay Detail
ADMET
CHEMBL4386409
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Inhibition of recombinant full-length C-terminal His-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells measured after 40 mins by HDAC-Glo1/2 luminescent assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.26 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.40 |
| CHEMBL4532181 | — | — | 1 | 5.70 |
| CHEMBL4541796 | — | — | 1 | 5.50 |
| CHEMBL4066920 | — | — | 1 | 5.20 |
| CHEMBL4578278 | — | — | 1 | 5.20 |
| CHEMBL4531802 | — | — | 1 | 5.10 |
| CHEMBL4470067 | — | — | 1 | 5.10 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.90 |
| CHEMBL3971436 | — | — | 1 | 4.90 |
| CHEMBL2018451 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4532181 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4541796 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4066920 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4578278 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4531802 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4470067 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3971436 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2018451 | — | IC50 | = | 25118.86 | nM | 4.60 |