Assay Detail
Binding
CHEMBL4386585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli OXA-48 assessed as reduction in breakdown of cephalosporin FC-5 in presence of 100 mM NaHCO3 by fluorescence method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Profiling interactions of vaborbactam with metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.04 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4533632 | — | — | 1 | 5.58 |
| CHEMBL3317857 | VABORBACTAM | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4533632 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3317857 | VABORBACTAM | IC50 | = | 32000.0 | nM | 4.50 |