Assay Detail
Binding
CHEMBL4386611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293T cells and using 5-FAM labelled-EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polypeptide N-acetylgalactosaminyltransferase 2 (CHEMBL3713355) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 6.29 |
| CHEMBL6338 | — | — | 1 | 6.12 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | 5.86 |
| CHEMBL1526978 | — | — | 1 | - |
| CHEMBL487203 | — | — | 1 | - |
| CHEMBL279564 | PYRENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL6338 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1526978 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL487203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL279564 | PYRENE | IC50 | > | 100000.0 | nM | - |