Assay Detail
Binding
CHEMBL4386612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation constant by SPR analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polypeptide N-acetylgalactosaminyltransferase 2 (CHEMBL3713355) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.33 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6338 | — | — | 1 | 6.53 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 6.43 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6338 | — | Kd | = | 294.0 | nM | 6.53 |
| CHEMBL6246 | ELLAGIC ACID | Kd | = | 371.0 | nM | 6.43 |
| CHEMBL288114 | GALLIC ACID | Kd | = | 924.0 | nM | 6.03 |