Assay Detail
Binding
CHEMBL4386713
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Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 9.84 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4557789 | — | — | 1 | 10.82 |
| CHEMBL4437858 | — | — | 1 | 10.82 |
| CHEMBL4473265 | — | — | 1 | 10.57 |
| CHEMBL4547877 | — | — | 1 | 10.55 |
| CHEMBL4587426 | — | — | 1 | 10.34 |
| CHEMBL4449384 | — | — | 1 | 10.20 |
| CHEMBL4450375 | — | — | 1 | 9.88 |
| CHEMBL4565239 | — | — | 1 | 9.87 |
| CHEMBL4583723 | — | — | 1 | 9.80 |
| CHEMBL4576714 | — | — | 1 | 9.78 |
| CHEMBL4440405 | — | — | 1 | 9.74 |
| CHEMBL4542363 | — | — | 1 | 9.58 |
| CHEMBL4588741 | — | — | 1 | 9.54 |
| CHEMBL2374220 | LEDIPASVIR | 4.0 | 1 | 6.28 |
| CHEMBL3545062 | VELPATASVIR | 4.0 | 1 | - |
| CHEMBL4467926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4557789 | — | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL4437858 | — | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL4473265 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL4547877 | — | EC50 | = | 0.028 | nM | 10.55 |
| CHEMBL4587426 | — | EC50 | = | 0.046 | nM | 10.34 |
| CHEMBL4449384 | — | EC50 | = | 0.063 | nM | 10.20 |
| CHEMBL4450375 | — | EC50 | = | 0.132 | nM | 9.88 |
| CHEMBL4565239 | — | EC50 | = | 0.135 | nM | 9.87 |
| CHEMBL4583723 | — | EC50 | = | 0.157 | nM | 9.80 |
| CHEMBL4576714 | — | EC50 | = | 0.166 | nM | 9.78 |
| CHEMBL4440405 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4542363 | — | EC50 | = | 0.265 | nM | 9.58 |
| CHEMBL4588741 | — | EC50 | = | 0.29 | nM | 9.54 |
| CHEMBL2374220 | LEDIPASVIR | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3545062 | VELPATASVIR | EC50 | = | 0.006 | nM | - |
| CHEMBL4467926 | — | EC50 | = | 0.009 | nM | - |