Assay Detail
Binding
CHEMBL4386717
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Inhibition of NS5A in HCV genotype 6e D88 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 6e |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.84 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588741 | — | — | 1 | 9.96 |
| CHEMBL3545062 | VELPATASVIR | 4.0 | 1 | 9.89 |
| CHEMBL4436929 | — | — | 1 | 8.94 |
| CHEMBL2374220 | LEDIPASVIR | 4.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588741 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3545062 | VELPATASVIR | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4436929 | — | EC50 | = | 1.16 | nM | 8.94 |
| CHEMBL2374220 | LEDIPASVIR | EC50 | = | 264.0 | nM | 6.58 |