Assay Detail
Binding
CHEMBL4386718
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Inhibition of NS5A in HCV genotype 2a JFH1 (L31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 10.42 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4575259 | — | — | 1 | 11.00 |
| CHEMBL4580476 | — | — | 1 | 10.85 |
| CHEMBL4579101 | — | — | 1 | 10.85 |
| CHEMBL4453135 | — | — | 1 | 10.80 |
| CHEMBL4466791 | — | — | 1 | 10.80 |
| CHEMBL4533239 | — | — | 1 | 10.72 |
| CHEMBL4550389 | — | — | 1 | 10.70 |
| CHEMBL4458486 | — | — | 1 | 10.70 |
| CHEMBL4437973 | — | — | 1 | 10.66 |
| CHEMBL4588951 | — | — | 1 | 10.66 |
| CHEMBL4442040 | — | — | 1 | 10.42 |
| CHEMBL4466693 | — | — | 1 | 10.14 |
| CHEMBL4542747 | — | — | 1 | 10.13 |
| CHEMBL3914296 | — | — | 1 | 9.88 |
| CHEMBL4469219 | — | — | 1 | 9.65 |
| CHEMBL4588138 | — | — | 1 | 8.83 |
| CHEMBL4466184 | — | — | 1 | - |
| CHEMBL4543321 | — | — | 1 | - |
| CHEMBL4562949 | — | — | 1 | - |
| CHEMBL4436929 | — | — | 1 | - |
| CHEMBL4536960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4575259 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4580476 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL4579101 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL4453135 | — | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL4466791 | — | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL4533239 | — | EC50 | = | 0.019 | nM | 10.72 |
| CHEMBL4550389 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4458486 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4437973 | — | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL4588951 | — | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL4442040 | — | EC50 | = | 0.038 | nM | 10.42 |
| CHEMBL4466693 | — | EC50 | = | 0.073 | nM | 10.14 |
| CHEMBL4542747 | — | EC50 | = | 0.074 | nM | 10.13 |
| CHEMBL3914296 | — | EC50 | = | 0.131 | nM | 9.88 |
| CHEMBL4469219 | — | EC50 | = | 0.223 | nM | 9.65 |
| CHEMBL4588138 | — | EC50 | = | 1.47 | nM | 8.83 |
| CHEMBL4466184 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL4543321 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4562949 | — | EC50 | = | 0.009 | nM | - |
| CHEMBL4436929 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL4536960 | — | EC50 | = | 0.004 | nM | - |