Assay Detail
Binding
CHEMBL4386726
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Inhibition of NS5A Q30R mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.29 | 10.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545062 | VELPATASVIR | 4.0 | 1 | 10.51 |
| CHEMBL4565239 | — | — | 1 | 9.66 |
| CHEMBL2374220 | LEDIPASVIR | 4.0 | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545062 | VELPATASVIR | EC50 | = | 0.031 | nM | 10.51 |
| CHEMBL4565239 | — | EC50 | = | 0.22 | nM | 9.66 |
| CHEMBL2374220 | LEDIPASVIR | EC50 | = | 19.6 | nM | 7.71 |