Assay Detail
Binding
CHEMBL4386778
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Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 10.87 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440405 | — | — | 1 | 11.00 |
| CHEMBL4583723 | — | — | 1 | 10.92 |
| CHEMBL4449384 | — | — | 1 | 10.85 |
| CHEMBL4519639 | — | — | 1 | 10.72 |
| CHEMBL4450375 | — | — | 1 | - |
| CHEMBL4542363 | — | — | 1 | - |
| CHEMBL4565239 | — | — | 1 | - |
| CHEMBL4576714 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440405 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4583723 | — | EC50 | = | 0.012 | nM | 10.92 |
| CHEMBL4449384 | — | EC50 | = | 0.014 | nM | 10.85 |
| CHEMBL4519639 | — | EC50 | = | 0.019 | nM | 10.72 |
| CHEMBL4450375 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL4542363 | — | EC50 | = | 0.007 | nM | - |
| CHEMBL4565239 | — | EC50 | = | 0.008 | nM | - |
| CHEMBL4576714 | — | EC50 | = | 0.009 | nM | - |