Assay Detail
Binding
CHEMBL4386779
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Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 3a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi<sup>®</sup> and Epclusa<sup>®</sup>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 10.46 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453135 | — | — | 1 | 10.92 |
| CHEMBL4467926 | — | — | 1 | 10.77 |
| CHEMBL4450375 | — | — | 1 | 10.74 |
| CHEMBL4587426 | — | — | 1 | 10.74 |
| CHEMBL4449384 | — | — | 1 | 10.70 |
| CHEMBL4437858 | — | — | 1 | 10.70 |
| CHEMBL4565239 | — | — | 1 | 10.62 |
| CHEMBL4547877 | — | — | 1 | 10.60 |
| CHEMBL4557789 | — | — | 1 | 10.60 |
| CHEMBL4542363 | — | — | 1 | 10.32 |
| CHEMBL4473265 | — | — | 1 | 10.30 |
| CHEMBL4436929 | — | — | 1 | 10.26 |
| CHEMBL4576714 | — | — | 1 | 10.24 |
| CHEMBL4583723 | — | — | 1 | 10.21 |
| CHEMBL4588741 | — | — | 1 | 9.92 |
| CHEMBL4440405 | — | — | 1 | 9.69 |
| CHEMBL4574152 | — | — | 1 | - |
| CHEMBL4457264 | — | — | 1 | - |
| CHEMBL4468617 | — | — | 1 | - |
| CHEMBL4516340 | — | — | 1 | - |
| CHEMBL4536960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453135 | — | EC50 | = | 0.012 | nM | 10.92 |
| CHEMBL4467926 | — | EC50 | = | 0.017 | nM | 10.77 |
| CHEMBL4450375 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL4587426 | — | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL4449384 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4437858 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4565239 | — | EC50 | = | 0.024 | nM | 10.62 |
| CHEMBL4547877 | — | EC50 | = | 0.025 | nM | 10.60 |
| CHEMBL4557789 | — | EC50 | = | 0.025 | nM | 10.60 |
| CHEMBL4542363 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL4473265 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4436929 | — | EC50 | = | 0.055 | nM | 10.26 |
| CHEMBL4576714 | — | EC50 | = | 0.058 | nM | 10.24 |
| CHEMBL4583723 | — | EC50 | = | 0.061 | nM | 10.21 |
| CHEMBL4588741 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4440405 | — | EC50 | = | 0.206 | nM | 9.69 |
| CHEMBL4574152 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL4457264 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4468617 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL4516340 | — | EC50 | = | 0.005 | nM | - |
| CHEMBL4536960 | — | EC50 | = | 0.004 | nM | - |