Assay Detail
Functional
CHEMBL4386829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NALM6 cells incubated for 3 days by CellTiter-Glo luminescent assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NALM-6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 6.07 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221919 | — | — | 1 | 6.89 |
| CHEMBL4447525 | — | — | 1 | 6.68 |
| CHEMBL4538858 | — | — | 1 | 6.64 |
| CHEMBL4590901 | — | — | 1 | 6.55 |
| CHEMBL4437330 | — | — | 1 | 6.51 |
| CHEMBL4456530 | — | — | 1 | 6.46 |
| CHEMBL4453910 | — | — | 1 | 6.43 |
| CHEMBL4588810 | — | — | 1 | 6.42 |
| CHEMBL221918 | — | — | 1 | 6.42 |
| CHEMBL4545071 | — | — | 1 | 6.38 |
| CHEMBL4466161 | — | — | 1 | 6.35 |
| CHEMBL4587423 | — | — | 1 | 6.25 |
| CHEMBL2313117 | — | — | 1 | 6.23 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.21 |
| CHEMBL2313116 | — | — | 1 | 6.21 |
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | 6.20 |
| CHEMBL3898128 | — | — | 1 | 6.16 |
| CHEMBL4466997 | — | — | 1 | 6.14 |
| CHEMBL4583939 | — | — | 1 | 6.10 |
| CHEMBL4467546 | — | — | 1 | 6.08 |
| CHEMBL2338696 | — | — | 1 | 6.07 |
| CHEMBL4589141 | — | — | 1 | 6.04 |
| CHEMBL4468315 | — | — | 1 | 6.04 |
| CHEMBL4529134 | — | — | 1 | 6.02 |
| CHEMBL4548075 | — | — | 1 | 6.02 |
| CHEMBL4442930 | — | — | 1 | 6.01 |
| CHEMBL4456314 | — | — | 1 | 6.00 |
| CHEMBL4434655 | — | — | 1 | 6.00 |
| CHEMBL4447437 | — | — | 1 | 5.98 |
| CHEMBL3397768 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221919 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4447525 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4538858 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4590901 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4437330 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4456530 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4453910 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4588810 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL221918 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4545071 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4466161 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4587423 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2313117 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2313116 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL536151 | IMD-0354 | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3898128 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4466997 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4583939 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4467546 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL2338696 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4589141 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4468315 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4529134 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4548075 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4442930 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4434655 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4456314 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4447437 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3397768 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4530693 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2088008 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2088014 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4473104 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3917212 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4535677 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4462360 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4457728 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4561813 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4456093 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4471043 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4452120 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4451144 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4438822 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4443869 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2313111 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4444499 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4574740 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2313109 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4472957 | — | IC50 | = | 2130.0 | nM | 5.67 |