Assay Detail
Binding
CHEMBL4387029
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Inhibition of Trypanosoma cruzi FPPS using DMAPP as substrate incubated for 30 mins measured by scintillation counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.83 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460779 | — | — | 1 | 7.47 |
| CHEMBL2326222 | — | — | 1 | 7.40 |
| CHEMBL261473 | — | — | 1 | 7.24 |
| CHEMBL4540565 | — | — | 1 | 7.22 |
| CHEMBL4464077 | — | — | 1 | 7.15 |
| CHEMBL4470596 | — | — | 1 | 7.07 |
| CHEMBL2326232 | — | — | 1 | 7.01 |
| CHEMBL4514861 | — | — | 1 | 6.87 |
| CHEMBL4589071 | — | — | 1 | 6.76 |
| CHEMBL259192 | — | — | 1 | 6.31 |
| CHEMBL4543493 | — | — | 1 | 6.21 |
| CHEMBL1765149 | — | — | 1 | 6.09 |
| CHEMBL4455942 | — | — | 1 | 6.04 |
| CHEMBL4450470 | — | — | 1 | - |
| CHEMBL3099275 | — | — | 1 | - |
| CHEMBL2326229 | — | — | 1 | - |
| CHEMBL3099279 | — | — | 1 | - |
| CHEMBL3099276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460779 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2326222 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL261473 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4540565 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4464077 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4470596 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2326232 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4514861 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4589071 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL259192 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4543493 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL1765149 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4455942 | — | IC50 | = | 915.0 | nM | 6.04 |
| CHEMBL4450470 | — | IC50 | - | — | - | |
| CHEMBL3099275 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2326229 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3099279 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3099276 | — | IC50 | > | 1000.0 | nM | - |