Assay Detail
Binding
CHEMBL4387031
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Inhibition of Toxoplasma gondii FPPS using DMAPP as substrate incubated for 30 mins measured by scintillation counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.08 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326222 | — | — | 1 | 7.89 |
| CHEMBL2326232 | — | — | 1 | 7.68 |
| CHEMBL3099275 | — | — | 1 | 7.46 |
| CHEMBL3099279 | — | — | 1 | 7.41 |
| CHEMBL4460779 | — | — | 1 | 7.29 |
| CHEMBL3099276 | — | — | 1 | 7.22 |
| CHEMBL2326229 | — | — | 1 | 7.16 |
| CHEMBL4470596 | — | — | 1 | 7.10 |
| CHEMBL4514861 | — | — | 1 | 7.10 |
| CHEMBL4464077 | — | — | 1 | 7.06 |
| CHEMBL1765149 | — | — | 1 | 7.03 |
| CHEMBL261473 | — | — | 1 | 7.02 |
| CHEMBL4455942 | — | — | 1 | 6.88 |
| CHEMBL259192 | — | — | 1 | 6.85 |
| CHEMBL4540565 | — | — | 1 | 6.61 |
| CHEMBL4450470 | — | — | 1 | 6.57 |
| CHEMBL4589071 | — | — | 1 | 6.54 |
| CHEMBL4543493 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326222 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2326232 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3099275 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3099279 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4460779 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3099276 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2326229 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4470596 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4514861 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4464077 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1765149 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL261473 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4455942 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL259192 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4540565 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4450470 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4589071 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4543493 | — | IC50 | = | 299.0 | nM | 6.52 |