Assay Detail
Binding
CHEMBL4387463
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Inhibition of HIV reverse transcriptase RNase H activity
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.16 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290940 | — | — | 1 | 7.50 |
| CHEMBL1270611 | — | — | 1 | 7.35 |
| CHEMBL3818057 | — | — | 1 | 6.19 |
| CHEMBL3414865 | — | — | 1 | 6.10 |
| CHEMBL572124 | — | — | 1 | 5.85 |
| CHEMBL4537833 | — | — | 1 | 5.72 |
| CHEMBL550937 | BETA-THUJAPLICINOL | — | 1 | 5.42 |
| CHEMBL4076949 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290940 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1270611 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3818057 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3414865 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL572124 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4537833 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL550937 | BETA-THUJAPLICINOL | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4076949 | — | IC50 | = | 7300.0 | nM | 5.14 |