Assay Detail
Binding
CHEMBL4387485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by SPR analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase SETDB1 (CHEMBL2321646) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 2.36 | 2.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455427 | — | — | 1 | 2.60 |
| CHEMBL4542222 | — | — | 1 | 2.57 |
| CHEMBL4576037 | — | — | 1 | 2.46 |
| CHEMBL4453131 | — | — | 1 | 2.40 |
| CHEMBL4589361 | — | — | 1 | 2.11 |
| CHEMBL4451286 | — | — | 1 | 2.00 |
| CHEMBL4461772 | — | — | 1 | - |
| CHEMBL4456448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455427 | — | Kd | = | 2500000.0 | nM | 2.60 |
| CHEMBL4542222 | — | Kd | = | 2700000.0 | nM | 2.57 |
| CHEMBL4576037 | — | Kd | = | 3500000.0 | nM | 2.46 |
| CHEMBL4453131 | — | Kd | = | 4000000.0 | nM | 2.40 |
| CHEMBL4589361 | — | Kd | = | 7700000.0 | nM | 2.11 |
| CHEMBL4451286 | — | Kd | = | 10000000.0 | nM | 2.00 |
| CHEMBL4461772 | — | Kd | - | — | - | |
| CHEMBL4456448 | — | Kd | = | 1270000.0 | nM | - |