Assay Detail
Binding
CHEMBL4387677
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Inhibition of HIV1 protease using Ac-Thr-Ile-Nle-Nle-Gln-Arg-NH2 substrate by continuous fluorometric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.32 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.80 |
| CHEMBL4444017 | — | — | 1 | 9.29 |
| CHEMBL4456725 | — | — | 1 | 8.35 |
| CHEMBL4467544 | — | — | 1 | 8.25 |
| CHEMBL4445644 | — | — | 1 | 7.51 |
| CHEMBL4469790 | — | — | 1 | 7.26 |
| CHEMBL4570048 | — | — | 1 | 6.70 |
| CHEMBL4474819 | — | — | 1 | 6.70 |
| CHEMBL4440087 | — | — | 1 | 6.64 |
| CHEMBL4558365 | — | — | 1 | 6.40 |
| CHEMBL4437581 | — | — | 1 | 6.33 |
| CHEMBL4556792 | — | — | 1 | 5.71 |
| CHEMBL4467187 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL4444017 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL4456725 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4467544 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL4445644 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL4469790 | — | Ki | = | 54.8 | nM | 7.26 |
| CHEMBL4570048 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL4474819 | — | Ki | = | 199.9 | nM | 6.70 |
| CHEMBL4440087 | — | Ki | = | 226.4 | nM | 6.64 |
| CHEMBL4558365 | — | Ki | = | 396.6 | nM | 6.40 |
| CHEMBL4437581 | — | Ki | = | 463.3 | nM | 6.33 |
| CHEMBL4556792 | — | Ki | = | 1957.0 | nM | 5.71 |
| CHEMBL4467187 | — | Ki | = | 6099.0 | nM | 5.21 |