Assay Detail
Binding
CHEMBL4388217
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Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.39 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472296 | — | — | 1 | 8.05 |
| CHEMBL4450586 | — | — | 1 | 7.05 |
| CHEMBL4440172 | — | — | 1 | 6.96 |
| CHEMBL4562342 | — | — | 1 | 6.85 |
| CHEMBL4572598 | — | — | 1 | 6.80 |
| CHEMBL4472335 | — | — | 1 | 6.72 |
| CHEMBL4447164 | — | — | 1 | 6.72 |
| CHEMBL4473575 | — | — | 1 | 6.68 |
| CHEMBL4562519 | — | — | 1 | 6.58 |
| CHEMBL4462158 | — | — | 1 | 6.51 |
| CHEMBL4583477 | — | — | 1 | 6.41 |
| CHEMBL4471156 | — | — | 1 | 6.04 |
| CHEMBL4455409 | — | — | 1 | 5.66 |
| CHEMBL4543531 | — | — | 1 | 5.52 |
| CHEMBL4473720 | — | — | 1 | 5.41 |
| CHEMBL4571341 | — | — | 1 | 5.37 |
| CHEMBL4456292 | — | — | 1 | 5.24 |
| CHEMBL4553424 | — | — | 1 | - |
| CHEMBL4556073 | — | — | 1 | - |
| CHEMBL4530520 | — | — | 1 | - |
| CHEMBL4565311 | — | — | 1 | - |
| CHEMBL4464304 | — | — | 1 | - |
| CHEMBL4561378 | — | — | 1 | - |
| CHEMBL4541851 | — | — | 1 | - |
| CHEMBL4466705 | — | — | 1 | - |
| CHEMBL4538569 | — | — | 1 | - |
| CHEMBL4447193 | — | — | 1 | - |
| CHEMBL4448878 | — | — | 1 | - |
| CHEMBL4438128 | — | — | 1 | - |
| CHEMBL4551142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472296 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4450586 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4440172 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4562342 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4572598 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4472335 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4447164 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4473575 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4562519 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4462158 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4583477 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4471156 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4455409 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4543531 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4473720 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4571341 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4456292 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4553424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4556073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530520 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4565311 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464304 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4561378 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4541851 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4466705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4538569 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4447193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4448878 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438128 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4551142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4561019 | — | IC50 | > | 10000.0 | nM | - |