Assay Detail
Binding
CHEMBL4388228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Leishmania major pteridine reductase 1 using di-hydrobiopterine as substrate in presence of NADPH
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.57 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95463 | — | — | 1 | 5.72 |
| CHEMBL4552119 | — | — | 1 | 5.61 |
| CHEMBL4582026 | — | — | 1 | 5.46 |
| CHEMBL4439011 | — | — | 1 | 5.00 |
| CHEMBL4564287 | — | — | 1 | 4.91 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.87 |
| CHEMBL4458858 | — | — | 1 | 4.82 |
| CHEMBL4441552 | — | — | 1 | 4.82 |
| CHEMBL4583705 | — | — | 1 | 4.82 |
| CHEMBL4581650 | — | — | 1 | 4.72 |
| CHEMBL4562350 | — | — | 1 | 4.52 |
| CHEMBL4456198 | — | — | 1 | 4.52 |
| CHEMBL4566383 | — | — | 1 | 4.50 |
| CHEMBL432942 | — | — | 1 | 4.48 |
| CHEMBL4579215 | — | — | 1 | 4.44 |
| CHEMBL4453795 | — | — | 1 | 4.43 |
| CHEMBL4577695 | — | — | 1 | 4.32 |
| CHEMBL4476655 | — | — | 1 | 4.30 |
| CHEMBL4469761 | — | — | 1 | 4.21 |
| CHEMBL4460492 | — | — | 1 | 4.19 |
| CHEMBL4540341 | — | — | 1 | 4.18 |
| CHEMBL4446494 | — | — | 1 | 4.18 |
| CHEMBL4561783 | — | — | 1 | 4.13 |
| CHEMBL4475811 | — | — | 1 | 4.09 |
| CHEMBL4468228 | — | — | 1 | 4.06 |
| CHEMBL4435791 | — | — | 1 | 4.05 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 4.03 |
| CHEMBL4465714 | — | — | 1 | - |
| CHEMBL2386433 | — | — | 1 | - |
| CHEMBL4528355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95463 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4552119 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4582026 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL4439011 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4564287 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL4458858 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4441552 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4583705 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4581650 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4562350 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4456198 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL4566383 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL432942 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL4579215 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4453795 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL4577695 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL4476655 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4469761 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL4460492 | — | IC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL4540341 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL4446494 | — | IC50 | = | 65900.0 | nM | 4.18 |
| CHEMBL4561783 | — | IC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL4475811 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL4468228 | — | IC50 | = | 86500.0 | nM | 4.06 |
| CHEMBL4435791 | — | IC50 | = | 88500.0 | nM | 4.05 |
| CHEMBL744 | RILUZOLE | IC50 | = | 94100.0 | nM | 4.03 |
| CHEMBL4465714 | — | IC50 | - | — | - | |
| CHEMBL2386433 | — | IC50 | - | — | - | |
| CHEMBL4528355 | — | IC50 | - | — | - | |
| CHEMBL4462566 | — | IC50 | - | — | - | |
| CHEMBL4444333 | — | IC50 | - | — | - |