Assay Detail
Binding
CHEMBL4388229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged Trypanosoma brucei pteridine reductase 1 using di-hydrobiopterine as substrate measured at 1 min interval for 50 mins in presence of NADPH
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.22 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.05 |
| CHEMBL4564287 | — | — | 1 | 6.46 |
| CHEMBL4562350 | — | — | 1 | 6.30 |
| CHEMBL95463 | — | — | 1 | 6.30 |
| CHEMBL4468228 | — | — | 1 | 6.17 |
| CHEMBL4439011 | — | — | 1 | 6.05 |
| CHEMBL4577695 | — | — | 1 | 6.04 |
| CHEMBL4441552 | — | — | 1 | 6.03 |
| CHEMBL4540341 | — | — | 1 | 5.77 |
| CHEMBL4475811 | — | — | 1 | 5.72 |
| CHEMBL4464690 | — | — | 1 | 5.52 |
| CHEMBL4566383 | — | — | 1 | 5.48 |
| CHEMBL4465714 | — | — | 1 | 5.47 |
| CHEMBL4458858 | — | — | 1 | 5.27 |
| CHEMBL4582026 | — | — | 1 | 5.19 |
| CHEMBL4581650 | — | — | 1 | 5.16 |
| CHEMBL4554707 | — | — | 1 | 5.12 |
| CHEMBL4469761 | — | — | 1 | 5.00 |
| CHEMBL4583705 | — | — | 1 | 4.94 |
| CHEMBL4444333 | — | — | 1 | 4.92 |
| CHEMBL2386433 | — | — | 1 | 4.87 |
| CHEMBL4460492 | — | — | 1 | 4.86 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 4.82 |
| CHEMBL4446494 | — | — | 1 | 4.82 |
| CHEMBL4462566 | — | — | 1 | 4.80 |
| CHEMBL4579215 | — | — | 1 | 4.78 |
| CHEMBL4435791 | — | — | 1 | 4.73 |
| CHEMBL4452155 | — | — | 1 | 4.66 |
| CHEMBL4528355 | — | — | 1 | 4.63 |
| CHEMBL4476655 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4564287 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL95463 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4562350 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4468228 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4439011 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4577695 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4441552 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4540341 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4475811 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4464690 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4566383 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4465714 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4458858 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4582026 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL4581650 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL4554707 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4469761 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4583705 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4444333 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2386433 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4460492 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL744 | RILUZOLE | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4446494 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4462566 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4579215 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL4435791 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL4452155 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4528355 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4476655 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL4456198 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4453795 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL432942 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4561783 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL4440584 | — | IC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL4452773 | — | IC50 | = | 58100.0 | nM | 4.24 |