Assay Detail
Functional
CHEMBL4388291
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Antiviral activity against Enterovirus D68 US/IL/14-18956 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect incubated for 5 mins under shaking condition and measured after 3 days by neutral red dye-based photometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | enterovirus D68 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.74 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4525860 | — | — | 1 | 7.30 |
| CHEMBL4517107 | — | — | 1 | 7.22 |
| CHEMBL2448988 | — | — | 1 | 6.70 |
| CHEMBL1086 | DIBUCAINE | 4.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4525860 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4517107 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2448988 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1086 | DIBUCAINE | EC50 | = | 1800.0 | nM | 5.75 |