Assay Detail
Functional
CHEMBL4388463
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.06 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475995 | — | — | 1 | 9.65 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.39 |
| CHEMBL4578113 | — | — | 1 | 9.22 |
| CHEMBL4540043 | — | — | 1 | 9.20 |
| CHEMBL4579284 | — | — | 1 | 9.04 |
| CHEMBL4453544 | — | — | 1 | 8.71 |
| CHEMBL4454520 | — | — | 1 | 8.44 |
| CHEMBL4522903 | — | — | 1 | 8.42 |
| CHEMBL4459869 | — | — | 1 | 8.40 |
| CHEMBL4562385 | — | — | 1 | 8.30 |
| CHEMBL4527968 | — | — | 1 | 8.23 |
| CHEMBL4453985 | — | — | 1 | 8.20 |
| CHEMBL4515592 | — | — | 1 | 7.90 |
| CHEMBL4561168 | — | — | 1 | 7.58 |
| CHEMBL4451832 | — | — | 1 | 7.44 |
| CHEMBL4451262 | — | — | 1 | 7.42 |
| CHEMBL4518604 | — | — | 1 | 7.37 |
| CHEMBL4470144 | — | — | 1 | 7.17 |
| CHEMBL4516605 | — | — | 1 | 7.02 |
| CHEMBL4454348 | — | — | 1 | 6.85 |
| CHEMBL4567362 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475995 | — | IC50 | = | 0.226 | nM | 9.65 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4578113 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4540043 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4579284 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL4453544 | — | IC50 | = | 1.97 | nM | 8.71 |
| CHEMBL4454520 | — | IC50 | = | 3.64 | nM | 8.44 |
| CHEMBL4522903 | — | IC50 | = | 3.84 | nM | 8.42 |
| CHEMBL4459869 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4562385 | — | IC50 | = | 5.03 | nM | 8.30 |
| CHEMBL4527968 | — | IC50 | = | 5.94 | nM | 8.23 |
| CHEMBL4453985 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4515592 | — | IC50 | = | 12.49 | nM | 7.90 |
| CHEMBL4561168 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL4451832 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4451262 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL4518604 | — | IC50 | = | 42.6 | nM | 7.37 |
| CHEMBL4470144 | — | IC50 | = | 67.8 | nM | 7.17 |
| CHEMBL4516605 | — | IC50 | = | 95.7 | nM | 7.02 |
| CHEMBL4454348 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4567362 | — | IC50 | = | 4120.0 | nM | 5.38 |