Assay Detail
Functional
CHEMBL4388514
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Antiproliferative activity against human NCI-H1299 cells after 72 hrs by cell titer glo assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of biaryl heterocycles as inhibitors of Wee1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.50 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4529353 | — | — | 1 | 7.22 |
| CHEMBL4444364 | — | — | 1 | 7.10 |
| CHEMBL4441166 | — | — | 1 | 7.00 |
| CHEMBL4526423 | — | — | 1 | 6.89 |
| CHEMBL4447769 | — | — | 1 | 6.85 |
| CHEMBL4554796 | — | — | 1 | 6.68 |
| CHEMBL3355539 | — | — | 1 | 6.51 |
| CHEMBL4470852 | — | — | 1 | 6.48 |
| CHEMBL4454675 | — | — | 1 | 6.41 |
| CHEMBL4551299 | — | — | 1 | 6.34 |
| CHEMBL4544916 | — | — | 1 | 6.30 |
| CHEMBL4443172 | — | — | 1 | 6.28 |
| CHEMBL4469678 | — | — | 1 | 5.76 |
| CHEMBL4450036 | — | — | 1 | 5.12 |
| CHEMBL4562919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4529353 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4444364 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4441166 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4526423 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4447769 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4554796 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3355539 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4470852 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4454675 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4551299 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4544916 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4443172 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4469678 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4450036 | — | EC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL4562919 | — | EC50 | > | 10000.0 | nM | - |