Assay Detail
Binding
CHEMBL4388902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma secretase in mouse Neuro2 cells expressing endogenous levels of amyloid precursor protein assessed as reduction in Abeta42 levels incubated for 18 hrs by sandwich ELISA
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.07 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541193 | — | — | 1 | 8.15 |
| CHEMBL2151205 | E-2212 | 1.0 | 1 | 7.96 |
| CHEMBL4521904 | — | — | 1 | 7.80 |
| CHEMBL4451760 | — | — | 1 | 7.77 |
| CHEMBL4458813 | — | — | 1 | 7.72 |
| CHEMBL4520168 | — | — | 1 | 7.72 |
| CHEMBL4549121 | — | — | 1 | 7.64 |
| CHEMBL4536918 | — | — | 1 | 7.55 |
| CHEMBL4544029 | — | — | 1 | 7.47 |
| CHEMBL4539673 | — | — | 1 | 7.44 |
| CHEMBL4516657 | — | — | 1 | 7.39 |
| CHEMBL4542879 | — | — | 1 | 7.38 |
| CHEMBL4446595 | — | — | 1 | 7.38 |
| CHEMBL4579909 | — | — | 1 | 7.34 |
| CHEMBL4466805 | — | — | 1 | 7.31 |
| CHEMBL4462407 | — | — | 1 | 7.30 |
| CHEMBL4591352 | — | — | 1 | 7.23 |
| CHEMBL4560947 | — | — | 1 | 7.13 |
| CHEMBL4591622 | — | — | 1 | 7.07 |
| CHEMBL4535866 | — | — | 1 | 7.07 |
| CHEMBL4524417 | — | — | 1 | 6.97 |
| CHEMBL4590743 | — | — | 1 | 6.78 |
| CHEMBL2151216 | — | — | 1 | 6.74 |
| CHEMBL4436587 | — | — | 1 | 6.73 |
| CHEMBL4582605 | — | — | 1 | 6.60 |
| CHEMBL4457660 | — | — | 1 | 6.56 |
| CHEMBL4449897 | — | — | 1 | 6.53 |
| CHEMBL4468761 | — | — | 1 | 6.47 |
| CHEMBL4527794 | — | — | 1 | 6.17 |
| CHEMBL4542411 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541193 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2151205 | E-2212 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4521904 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4451760 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4458813 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4520168 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4549121 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4536918 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4544029 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4539673 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4516657 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4542879 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4446595 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4579909 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4466805 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4462407 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4591352 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4560947 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4591622 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4535866 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4524417 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4590743 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL2151216 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4436587 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4582605 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL4457660 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4449897 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4468761 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4527794 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4542411 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4435638 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4474036 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4474638 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4534560 | — | IC50 | > | 10000.0 | nM | - |