Assay Detail
Binding
CHEMBL4388922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich ELISA
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.17 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4451760 | — | — | 1 | 7.85 |
| CHEMBL4471286 | — | — | 1 | 7.82 |
| CHEMBL4563162 | — | — | 1 | 7.77 |
| CHEMBL4458813 | — | — | 1 | 7.75 |
| CHEMBL4466805 | — | — | 1 | 7.72 |
| CHEMBL4587055 | — | — | 1 | 7.66 |
| CHEMBL4521904 | — | — | 1 | 7.64 |
| CHEMBL4536918 | — | — | 1 | 7.60 |
| CHEMBL4549121 | — | — | 1 | 7.58 |
| CHEMBL4520168 | — | — | 1 | 7.51 |
| CHEMBL4544029 | — | — | 1 | 7.50 |
| CHEMBL4539673 | — | — | 1 | 7.44 |
| CHEMBL4542879 | — | — | 1 | 7.44 |
| CHEMBL4535885 | — | — | 1 | 7.41 |
| CHEMBL4560947 | — | — | 1 | 7.39 |
| CHEMBL4446595 | — | — | 1 | 7.35 |
| CHEMBL4591352 | — | — | 1 | 7.23 |
| CHEMBL4558822 | — | — | 1 | 7.18 |
| CHEMBL4516657 | — | — | 1 | 7.14 |
| CHEMBL4524417 | — | — | 1 | 7.01 |
| CHEMBL4590743 | — | — | 1 | 6.97 |
| CHEMBL4535866 | — | — | 1 | 6.96 |
| CHEMBL4462407 | — | — | 1 | 6.95 |
| CHEMBL4436587 | — | — | 1 | 6.93 |
| CHEMBL4468761 | — | — | 1 | 6.66 |
| CHEMBL4582605 | — | — | 1 | 6.46 |
| CHEMBL4449897 | — | — | 1 | 6.22 |
| CHEMBL4474036 | — | — | 1 | 5.40 |
| CHEMBL4534560 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4451760 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4471286 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4563162 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4458813 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4466805 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4587055 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4521904 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4536918 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4549121 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4520168 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4544029 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4539673 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4542879 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4535885 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4560947 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4446595 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4591352 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4558822 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4516657 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4524417 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4590743 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4535866 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4462407 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4436587 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4468761 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL4582605 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL4449897 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4474036 | — | IC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL4534560 | — | IC50 | = | 4000.0 | nM | 5.40 |