Assay Detail
Binding
CHEMBL4389012
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Inhibition of Trypanosoma cruzi glucokinase using D-glucose as substrate in presence of ATP and NADPH measured for every 30 secs for 10 mins by resazurin dye based G6PDH-diaphorase coupled fluorescence assay relative to control
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of antichagasic inhibitors by high-throughput screening with Trypanosoma cruzi glucokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.22 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2430368 | — | — | 1 | 6.52 |
| CHEMBL1538870 | — | — | 1 | 6.05 |
| CHEMBL4465026 | — | — | 1 | 5.80 |
| CHEMBL3290401 | — | — | 1 | 5.51 |
| CHEMBL4450527 | — | — | 1 | 5.32 |
| CHEMBL4446779 | — | — | 1 | 5.28 |
| CHEMBL404233 | — | — | 1 | 5.26 |
| CHEMBL4524315 | — | — | 1 | 5.21 |
| CHEMBL4541679 | — | — | 1 | 5.10 |
| CHEMBL141159 | — | — | 1 | 5.06 |
| CHEMBL4516907 | — | — | 1 | 4.84 |
| CHEMBL4541264 | — | — | 1 | 4.78 |
| CHEMBL1348016 | — | — | 1 | 4.77 |
| CHEMBL4473339 | — | — | 1 | 4.52 |
| CHEMBL4515993 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2430368 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1538870 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4465026 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3290401 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4450527 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4446779 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL404233 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4524315 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4541679 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL141159 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4516907 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4541264 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL1348016 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4473339 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4515993 | — | IC50 | = | 53200.0 | nM | 4.27 |