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Assay Detail

CHEMBL4390123

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Dengue virus serotype 2 NS2B-NS3 protease preincubated with protein for 15 mins followed by Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr substrate addition and measured by continuous fluorometric analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism dengue virus type 2
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Genome polyprotein (CHEMBL5980)
Type SINGLE PROTEIN
Organism dengue virus type 2

Publication

Backbone modifications in peptidic inhibitors of flaviviral proteases.
Jakob AKMH, Sundermann TR, Klein CD.
Bioorg Med Chem Lett (2019) 29 : 1913 -1917
PubMed 31176698 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.66 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3741422 1 6.40
CHEMBL4469272 1 6.22
CHEMBL4464884 1 5.89
CHEMBL4545026 1 5.80
CHEMBL4474101 1 5.52
CHEMBL3335494 1 5.48
CHEMBL4563546 1 5.44
CHEMBL3740277 1 5.42
CHEMBL4519077 1 5.39
CHEMBL4519543 1 5.02
CHEMBL4469131 1 -
CHEMBL4476608 1 -
CHEMBL4468720 1 -
CHEMBL4442641 1 -
CHEMBL4527041 1 -
CHEMBL4436871 1 -
CHEMBL4470468 1 -
CHEMBL4469492 1 -
CHEMBL4548502 1 -
CHEMBL4574992 1 -
CHEMBL4438710 1 -
CHEMBL4587765 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3741422 IC50 = 400.0 nM 6.40
CHEMBL4469272 IC50 = 600.0 nM 6.22
CHEMBL4464884 IC50 = 1300.0 nM 5.89
CHEMBL4545026 IC50 = 1600.0 nM 5.80
CHEMBL4474101 IC50 = 3000.0 nM 5.52
CHEMBL3335494 IC50 = 3300.0 nM 5.48
CHEMBL4563546 IC50 = 3600.0 nM 5.44
CHEMBL3740277 IC50 = 3800.0 nM 5.42
CHEMBL4519077 IC50 = 4100.0 nM 5.39
CHEMBL4519543 IC50 = 9500.0 nM 5.02
CHEMBL4469131 IC50 - -
CHEMBL4476608 IC50 - -
CHEMBL4468720 IC50 - -
CHEMBL4442641 IC50 - -
CHEMBL4527041 IC50 - -
CHEMBL4436871 IC50 - -
CHEMBL4470468 IC50 - -
CHEMBL4469492 IC50 - -
CHEMBL4548502 IC50 - -
CHEMBL4574992 IC50 - -
CHEMBL4438710 IC50 - -
CHEMBL4587765 IC50 - -