Assay Detail
Binding
CHEMBL4390133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta-gami B (DE3) assessed as reduction in consumption of NADPH using DHFA as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.53 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52947 | — | — | 1 | 5.85 |
| CHEMBL424135 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52947 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL424135 | — | IC50 | = | 6100.0 | nM | 5.21 |