Assay Detail
Functional
CHEMBL4390280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.74 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 9.74 |
| CHEMBL4550879 | — | — | 1 | - |
| CHEMBL4442132 | — | — | 1 | - |
| CHEMBL4447096 | — | — | 1 | - |
| CHEMBL4460287 | — | — | 1 | - |
| CHEMBL4469555 | — | — | 1 | - |
| CHEMBL4453936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4550879 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4442132 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4447096 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4460287 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4469555 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4453936 | — | EC50 | > | 100000.0 | nM | - |