Assay Detail
Binding
CHEMBL4390493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC1 expressed in baculovirus expression system using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.54 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 9.22 |
| CHEMBL4549278 | — | — | 1 | 8.24 |
| CHEMBL4476140 | — | — | 1 | 8.15 |
| CHEMBL4558240 | — | — | 1 | - |
| CHEMBL4467203 | — | — | 1 | - |
| CHEMBL4437857 | — | — | 1 | - |
| CHEMBL4554150 | — | — | 1 | - |
| CHEMBL4465985 | — | — | 1 | - |
| CHEMBL4519918 | — | — | 1 | - |
| CHEMBL4454438 | — | — | 1 | - |
| CHEMBL4539693 | — | — | 1 | - |
| CHEMBL4578621 | — | — | 1 | - |
| CHEMBL4448341 | — | — | 1 | - |
| CHEMBL4569947 | — | — | 1 | - |
| CHEMBL4531989 | — | — | 1 | - |
| CHEMBL4532028 | — | — | 1 | - |
| CHEMBL4513637 | — | — | 1 | - |
| CHEMBL4445944 | — | — | 1 | - |
| CHEMBL4545344 | — | — | 1 | - |
| CHEMBL4450509 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
| CHEMBL4466310 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4549278 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4476140 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4558240 | — | IC50 | - | — | - | |
| CHEMBL4467203 | — | IC50 | - | — | - | |
| CHEMBL4437857 | — | IC50 | - | — | - | |
| CHEMBL4554150 | — | IC50 | - | — | - | |
| CHEMBL4465985 | — | IC50 | - | — | - | |
| CHEMBL4519918 | — | IC50 | - | — | - | |
| CHEMBL4454438 | — | IC50 | - | — | - | |
| CHEMBL4539693 | — | IC50 | - | — | - | |
| CHEMBL4578621 | — | IC50 | - | — | - | |
| CHEMBL4448341 | — | IC50 | - | — | - | |
| CHEMBL4569947 | — | IC50 | - | — | - | |
| CHEMBL4531989 | — | IC50 | - | — | - | |
| CHEMBL4532028 | — | IC50 | - | — | - | |
| CHEMBL4513637 | — | IC50 | - | — | - | |
| CHEMBL4445944 | — | IC50 | - | — | - | |
| CHEMBL4545344 | — | IC50 | - | — | - | |
| CHEMBL4450509 | — | IC50 | - | — | - | |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - | |
| CHEMBL14762 | SELICICLIB | IC50 | - | — | - | |
| CHEMBL4466310 | — | IC50 | - | — | - |