Assay Detail
Functional
CHEMBL4390499
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Antiproliferative activity against human CAL148 cells measured after 72 hrs by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-148 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.18 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476140 | — | — | 1 | 6.41 |
| CHEMBL4549278 | — | — | 1 | 5.94 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | - |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476140 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4549278 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | < | 100.0 | nM | - |
| CHEMBL14762 | SELICICLIB | IC50 | > | 10000.0 | nM | - |