Assay Detail
Binding
CHEMBL4390730
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Inhibition of Synechocystis sp. PCC6803 PDHC-E1 expressed in Escherichia coli BL-21 (DE3) using 6-DCIP and pyruvate incubated for 5 mins
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Synechocystis sp. PCC 6803 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel inhibitors against cyanobacterial pyruvate dehydrogenase multienzyme complex E1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.59 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446650 | — | — | 1 | 5.83 |
| CHEMBL4536626 | — | — | 1 | 5.79 |
| CHEMBL4551831 | — | — | 1 | 5.77 |
| CHEMBL4573921 | — | — | 1 | 5.75 |
| CHEMBL4528072 | — | — | 1 | 5.73 |
| CHEMBL4468855 | — | — | 1 | 5.71 |
| CHEMBL4439522 | — | — | 1 | 5.63 |
| CHEMBL4440566 | — | — | 1 | 5.47 |
| CHEMBL4467832 | — | — | 1 | 5.45 |
| CHEMBL4448597 | — | — | 1 | 5.45 |
| CHEMBL4450631 | — | — | 1 | 5.45 |
| CHEMBL4451777 | — | — | 1 | 5.43 |
| CHEMBL4440722 | — | — | 1 | 5.41 |
| CHEMBL4455708 | — | — | 1 | 5.35 |
| CHEMBL1945267 | — | — | 1 | - |
| CHEMBL4462729 | — | — | 1 | - |
| CHEMBL1929455 | — | — | 1 | - |
| CHEMBL1929457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446650 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4536626 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4551831 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4573921 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4528072 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4468855 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4439522 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4440566 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4467832 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4448597 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4450631 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL4451777 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4440722 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4455708 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL1945267 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4462729 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1929455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1929457 | — | IC50 | > | 100000.0 | nM | - |