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Assay Detail

CHEMBL4390742

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NU04 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors.
Yang S, Shergalis A, Lu D, Kyani A, Liu Z, Ljungman M, Neamati N.
J Med Chem (2019) 62 : 3447 -3474
PubMed 30759340 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.88 5.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4446669 1 5.42
CHEMBL4464788 1 5.31
CHEMBL4459949 1 5.30
CHEMBL4470548 1 5.12
CHEMBL4449607 1 5.01
CHEMBL4472807 1 5.00
CHEMBL4520670 1 4.99
CHEMBL4537633 1 4.98
CHEMBL4519381 1 4.97
CHEMBL4513992 1 4.89
CHEMBL4459634 1 4.89
CHEMBL4584988 1 4.81
CHEMBL4545330 1 4.80
CHEMBL4550951 1 4.80
CHEMBL4472710 1 4.76
CHEMBL4460678 1 4.73
CHEMBL4577143 1 4.72
CHEMBL4572589 1 4.70
CHEMBL4483086 1 4.64
CHEMBL4438947 1 4.64
CHEMBL4567542 1 4.58
CHEMBL4447323 1 4.58
CHEMBL4520508 1 4.51
CHEMBL4560739 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4446669 IC50 = 3800.0 nM 5.42
CHEMBL4464788 IC50 = 4900.0 nM 5.31
CHEMBL4459949 IC50 = 5000.0 nM 5.30
CHEMBL4470548 IC50 = 7600.0 nM 5.12
CHEMBL4449607 IC50 = 9800.0 nM 5.01
CHEMBL4472807 IC50 = 9900.0 nM 5.00
CHEMBL4520670 IC50 = 10300.0 nM 4.99
CHEMBL4537633 IC50 = 10400.0 nM 4.98
CHEMBL4519381 IC50 = 10600.0 nM 4.97
CHEMBL4513992 IC50 = 13000.0 nM 4.89
CHEMBL4459634 IC50 = 12800.0 nM 4.89
CHEMBL4584988 IC50 = 15500.0 nM 4.81
CHEMBL4545330 IC50 = 15700.0 nM 4.80
CHEMBL4550951 IC50 = 15800.0 nM 4.80
CHEMBL4472710 IC50 = 17200.0 nM 4.76
CHEMBL4460678 IC50 = 18700.0 nM 4.73
CHEMBL4577143 IC50 = 19200.0 nM 4.72
CHEMBL4572589 IC50 = 19900.0 nM 4.70
CHEMBL4483086 IC50 = 22700.0 nM 4.64
CHEMBL4438947 IC50 = 22900.0 nM 4.64
CHEMBL4567542 IC50 = 26200.0 nM 4.58
CHEMBL4447323 IC50 = 26600.0 nM 4.58
CHEMBL4520508 IC50 = 30600.0 nM 4.51
CHEMBL4560739 IC50 - -