Assay Detail
ADMET
CHEMBL4390751
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Cytotoxicity against HFF1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HFF-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.66 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459949 | — | — | 1 | 5.47 |
| CHEMBL4483086 | — | — | 1 | 4.76 |
| CHEMBL4464788 | — | — | 1 | 4.65 |
| CHEMBL4470548 | — | — | 1 | 4.54 |
| CHEMBL4446669 | — | — | 1 | 4.50 |
| CHEMBL4545330 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459949 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4483086 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4464788 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4470548 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4446669 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4545330 | — | IC50 | = | 91200.0 | nM | 4.04 |