Assay Detail
ADMET
CHEMBL4391173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593316 | — | — | 1 | 5.80 |
| CHEMBL4443989 | — | — | 1 | 5.52 |
| CHEMBL4446287 | — | — | 1 | 5.52 |
| CHEMBL4559936 | — | — | 1 | 5.30 |
| CHEMBL4443468 | — | — | 1 | 5.22 |
| CHEMBL4516356 | — | — | 1 | 5.16 |
| CHEMBL4537026 | — | — | 1 | 4.57 |
| CHEMBL4583650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593316 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4443989 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4446287 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4559936 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4443468 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4516356 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4537026 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4583650 | — | IC50 | > | 25000.0 | nM | - |