Assay Detail
ADMET
CHEMBL4391174
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Cytotoxicity against human NCI-H727 cells assessed as growth inhibition incubated for 48 hrs by Hoechst 33342 staining based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NCI-H727 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.30 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559936 | — | — | 1 | 5.70 |
| CHEMBL4446287 | — | — | 1 | 5.40 |
| CHEMBL4443989 | — | — | 1 | 5.30 |
| CHEMBL4593316 | — | — | 1 | 5.20 |
| CHEMBL4443468 | — | — | 1 | 5.16 |
| CHEMBL4516356 | — | — | 1 | 5.05 |
| CHEMBL4537026 | — | — | 1 | - |
| CHEMBL4583650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559936 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4446287 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4443989 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4593316 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4443468 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4516356 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4537026 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4583650 | — | IC50 | > | 25000.0 | nM | - |