Assay Detail
Functional
CHEMBL4391801
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel α-acyloxy carboxamides via Passerini reaction as caspase 3/7 activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.21 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572642 | — | — | 1 | 8.11 |
| CHEMBL4452355 | — | — | 1 | 8.03 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.00 |
| CHEMBL4483079 | — | — | 1 | 7.85 |
| CHEMBL4470597 | — | — | 1 | 7.85 |
| CHEMBL4444346 | — | — | 1 | 7.75 |
| CHEMBL4542198 | — | — | 1 | 7.67 |
| CHEMBL4457138 | — | — | 1 | 7.66 |
| CHEMBL4587937 | — | — | 1 | 7.54 |
| CHEMBL4531962 | — | — | 1 | 7.47 |
| CHEMBL4517018 | — | — | 1 | 7.44 |
| CHEMBL4451006 | — | — | 1 | 7.41 |
| CHEMBL4581075 | — | — | 1 | 7.36 |
| CHEMBL4476481 | — | — | 1 | 7.28 |
| CHEMBL4474493 | — | — | 1 | 7.24 |
| CHEMBL4582711 | — | — | 1 | 7.21 |
| CHEMBL4455197 | — | — | 1 | 6.55 |
| CHEMBL4474327 | — | — | 1 | 6.37 |
| CHEMBL4464653 | — | — | 1 | 6.29 |
| CHEMBL4452570 | — | — | 1 | 6.29 |
| CHEMBL4516932 | — | — | 1 | 6.19 |
| CHEMBL3194066 | — | — | 1 | 6.18 |
| CHEMBL4457766 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572642 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4452355 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4483079 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL4470597 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL4444346 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4542198 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL4457138 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL4587937 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL4531962 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL4517018 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4451006 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL4581075 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4476481 | — | IC50 | = | 52.91 | nM | 7.28 |
| CHEMBL4474493 | — | IC50 | = | 57.1 | nM | 7.24 |
| CHEMBL4582711 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL4455197 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL4474327 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4464653 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL4452570 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL4516932 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL3194066 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL4457766 | — | IC50 | = | 734.0 | nM | 6.13 |