Assay Detail
ADMET
CHEMBL4391937
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.00 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449083 | — | — | 1 | 5.38 |
| CHEMBL4556281 | — | — | 1 | 5.31 |
| CHEMBL4559593 | — | — | 1 | 5.29 |
| CHEMBL4586157 | — | — | 1 | 5.25 |
| CHEMBL4555818 | — | — | 1 | 5.22 |
| CHEMBL4456435 | — | — | 1 | 5.03 |
| CHEMBL4467355 | — | — | 1 | 4.80 |
| CHEMBL4540429 | — | — | 1 | 4.58 |
| CHEMBL292314 | — | — | 1 | 4.15 |
| CHEMBL1256415 | — | — | 1 | - |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL4538398 | — | — | 1 | - |
| CHEMBL4556372 | — | — | 1 | - |
| CHEMBL4475391 | — | — | 1 | - |
| CHEMBL4472570 | — | — | 1 | - |
| CHEMBL4582203 | — | — | 1 | - |
| CHEMBL4444822 | — | — | 1 | - |
| CHEMBL4541558 | — | — | 1 | - |
| CHEMBL4552440 | — | — | 1 | - |
| CHEMBL4563209 | — | — | 1 | - |
| CHEMBL4466307 | — | — | 1 | - |
| CHEMBL4459500 | — | — | 1 | - |
| CHEMBL4438120 | — | — | 1 | - |
| CHEMBL4459416 | — | — | 1 | - |
| CHEMBL4556575 | — | — | 1 | - |
| CHEMBL4559477 | — | — | 1 | - |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449083 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4556281 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4559593 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4586157 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4555818 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4456435 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4467355 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4540429 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL292314 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL1256415 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL95 | TACRINE | IC50 | = | 190000.0 | nM | - |
| CHEMBL4538398 | — | IC50 | - | — | - | |
| CHEMBL4556372 | — | IC50 | - | — | - | |
| CHEMBL4475391 | — | IC50 | - | — | - | |
| CHEMBL4472570 | — | IC50 | - | — | - | |
| CHEMBL4582203 | — | IC50 | - | — | - | |
| CHEMBL4444822 | — | IC50 | - | — | - | |
| CHEMBL4541558 | — | IC50 | - | — | - | |
| CHEMBL4552440 | — | IC50 | - | — | - | |
| CHEMBL4563209 | — | IC50 | - | — | - | |
| CHEMBL4466307 | — | IC50 | - | — | - | |
| CHEMBL4459500 | — | IC50 | - | — | - | |
| CHEMBL4438120 | — | IC50 | - | — | - | |
| CHEMBL4459416 | — | IC50 | - | — | - | |
| CHEMBL4556575 | — | IC50 | - | — | - | |
| CHEMBL4559477 | — | IC50 | - | — | - | |
| CHEMBL54976 | TRYPTOPHAN | IC50 | = | 17000000.0 | nM | - |